LANSOPRAZOLE — Side Effects and Special Considerations

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    Lansoprazole, like other proton-pump inhibitors, is well-tolerated. Side effects include, but is not limited to:

    1. diarrhea
    2. nausea
    3. vomiting
    4. constipation
    5. rash
    6. headaches
    7. Dizziness
    8. nervousness
    9. abnormal heartbeat
    10. muscle pain
    11. weakness
    12. leg cramps
    13. water retention

    *Vitamin B-12 deficiency characterized by:
    1. nervousness
    2. neuritis (inflammation of a nerve)
    3. numbness and tingling in your hands and feet
    4. poor muscular coordination
    5. changes in menstruation

    *Low magnesium levels characterized by:
    1. seizures
    2. dizziness
    3. abnormal or fast heart rate
    4. jitters
    5. tremors (jerking movements or shaking)
    6. muscle weakness
    7. spasms in your hands and feet
    8. cramps or muscle aches
    9. spasms of your voice box

    *Serious allergic reactions characterized by:
    1. rash
    2. swelling of your face
    3. throat tightness
    4. trouble breathing

    *Diarrhea from bacterial infection characterized by:
    1. stomach pain
    2. watery diarrhea
    3. fever

    *Bone fractures

    *Kidney damage characterized by:
    1. flank pain (pain in your side and back)
    2. changes in urination


    1. The following drugs should not be used with lansoprazole:
    a. HIV drugs, such as atazanavir, nelfinavir, and drugs that contain rilpivirine
    b. HIV drugs, such as saquinavir
    c. Warfarin
    d. Digoxin
    e. Methotrexate
    f. Tacrolimus
    g. Sucralfate
    h. Rifampin
    i. St. John’s wort
    j. Ampicillin
    k. Ketoconazole and itraconazole
    l. Mycophenolate mofetil (MMF)
    m. Iron salts
    n. Erlotinib, dasatinib, and nilotinib
    o. Theophylline

    2. This medication can cause severe allergic recation and must not be taken again if ever you’ve had an allergic reaction to it before.

    3. Warnings are given for people with health conditions such as:
    a. liver problems
    b. vitamin B-12 deficiency
    c. osteoporosis
    d. low magnesium levels

    4. It isn’t known if lansoprazole passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child.


    I was diagnosed with diabetes and am now on metformin tablets. Can I take Lansoprazole with Metformin?


    Yes, you can take lansoprazole together with metformin. There are no recorded drug interaction between the two medications.


    Is there a difference between Dexilant and lansoprazole? Would it be possible to switch from Dexilant to lansoprazole? Dexilant is burning a hole in my pocket.


    Dexilant (dexlansoprazole) and lansoprazole belongs to the same drug classification called Proton Pump Inhibitor (PPI) which suppresses gastric acid secretion by preventing it from going into the stomach. Therefore, since both are chemically related, you generally won’t have any problem switching from Dexilant to lansoprazole. However, different people may find that one works better than the other for them. And if you have any significant health problems or taking other medications, it would still be wise to talk with your doctor regarding your intention to switch medication.

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