MONTELUKAST — Side Effects and Special Considerations

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    Montelukast may cause side effects which includes, but is not limited to:

    1. headache
    2. heartburn
    3. stomach pain
    4. tiredness
    5. diarrhea

    Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, consult with your doctor.

    1. Behavior and mood changes characterized by:
    a. feeling anxious
    b. bad or vivid dreams
    c. sleepwalking
    d. agitation
    e. restlessness
    f. tremor
    g. trouble sleeping
    h. suicidal thoughts or actions
    i. hallucinations
    j. confusion

    2. Increase white blood cells as characterized by:
    a. numbness in the arms or legs
    b. flu-like symptoms such as fever, muscle aches, or cold sweats

    3. Systemic inflammation of blood vessels as characterized by:
    a. Feeling of “pins and needles” or numbness in the arms or legs
    b. flu-like symptoms such as fever, muscle aches, or cold sweats
    c. severe pain and swelling of the sinuses

    4. Increased bleeding as characterized by:
    a. bleeding under the skin
    b. longer bleeding from cuts
    c. blood in the urine or feces

    5. Stevens-Johnson syndrome characterized by:
    a. swelling of the face or tongue
    b. hives
    c. skin pain
    d. a purple or red rash
    *This is a medical emergency.

    6. Uncontrolled muscle movements such as tics.

    1. This medication should not be used f you have a sudden asthma attack.

    2. This may increase risk of mental health problems such as agitation, aggressive behavior, hostility, anxiousness, depression, confusion, vivid dreams, hallucinations, trouble sleeping, irritability, or suicidal thoughts or actions.

    3. This medication may increase your risk of certain immune system problems such as systemic eosinophilia with vasculitis, and Churg-Strauss syndrome.


    I had been diagnosed with gastritis last month and feel a significant increase in acidity since four days ago. That was the day that I started taking montelukast as prescribed by my doctor. Could it be the medicine that caused it?


    Yes, it could have been the montelukast that caused the increase in acidity. This medication may cause dyspepsia and nausea for some. If it doesn’t go away in a few more days and keeps bothering you, let your doctor know so he could adjust your dose or change your medication if needed.


    Can Bactrim be taken together with montelukast?


    There is a moderate interaction between Bactrim and montelukast.

    The Sulfamethoxazole in Bactrim may enhance the effects of montelukast. So if you need to take both, a dose adjustment may be needed. Otherwise, a close monitoring by your doctor is essential to safely use both.


    Ever since I’ve started taking montelukast, even if I continue with my diet and do exercises, instead of losing weight, I have been gaining weight. Could it be because of the medication?


    Weight gain isn’t listed as a known side effect of this medication. Unlike antihistamines that blocks the histamine receptor leading to decreased metabolism, montelukast does not. This is because it is not an antihistamine, but a leukotriene receptor antagonist. Thus, your weight gain may be caused by other factors.


    How long does it take for this drug to take effect?


    The effectiveness of the medicine is immediate (the mechanism of action being to reduce leukotriene levels in the body). However, maximum effect is experienced in one week.


    Have you heard there’s a possible treatment of Covid-19 in taking Montelukast? It’s a possible study with the explanation that its anti-inflammatory properties and its ability to reduce oxidative stress may help in the progression of any disease in Covid-19 infections.


    That sounds like good news to me. Thinking about it, it’s no wonder it’s a suggestive treatment since most cases and mortality were due to respiratory failure from Covid-19 infections.


    I’ve read an article that supports your statements. It may reduce the severity of respiratory cases from Covid-19 infections and had shown significant decrease in the people at risk


    It is a promising research going on as we speak. Let’s hope for the best. =)


    I really wish the studies will prove that montelukast is effective against Covid-19 so I would feel less anxiety towards this pandemic knowing I have been taking an effective drug against it.

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