NALTREXONE — Side Effects and Special Considerations

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    1. Using this medicine with any of the following medicines is not recommended:
    a. Alfentanil
    b. Anileridine
    c. Benzhydrocodone
    d. Buprenorphine
    e. Butorphanol
    f. Codeine
    g. Diacetylmorphine
    h. Difenoxin
    i. Dihydrocodeine
    j. Diphenoxylate
    k. Ethylmorphine
    l. Fentanyl
    m. Hydrocodone
    n. Hydromorphone
    o. Ketobemidone
    p. Levorphanol
    q. Meperidine
    r. Methadone
    s. Morphine
    t. Morphine Sulfate Liposome
    u. Nalbuphine
    v. Nicomorphine
    w. Opium
    x. Opium Alkaloids
    y. Oxycodone
    z. Oxymorphone
    aa. Papaveretum
    ab. Paregoric
    ac. Piritramide
    ad. Propoxyphene
    ae. Remifentanil
    af. Sufentanil
    ag. Tapentadol
    ah. Tilidine
    ai. Tramadol

    2. Those with the following health condition must inform the doctor of these:
    a. Depression
    b. Mental illness
    c. Failed the naloxone challenge test (medical test to check your dependence to opioid medicine)
    d. Opioid withdrawal
    e. Positive urine test for opioids
    e. Receiving opioid analgesics (eg, buprenorphine, methadone, morphine)
    f. Kidney disease
    g. Liver disease (including cirrhosis, hepatitis B or C)

    3. You will need to stop using opioids (narcotics) for at least 7 to 10 days before you can start taking naltrexone.

    4. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


    Does a person feel high or down when being medicated with naltrexone?


    Aside from side effects of naltrexone such as nausea, headache, dizziness or tiredness, that are usually mild and does not last long, patients are generally unaware of being on medications because naltrexone, most of the time, has no psychological effects. This means that patients don’t feel either “high” or “down”. This medication is non-addicting, and even though it reduces alcohol craving, it does not interfere with the experience of other types of pleasure.


    I am taking Contrave that contains naltrexone. Should I take this medication before or after my meal?


    Hi Theodore, Contrave should be taken in the morning and in the evening. The tablets should not be cut, chewed, or crushed. It should be taken whole. In clinical trials, the medication was administered with meals. However, high-fat meal must be avoided because it results to an increase in bupropion and naltrexone systemic exposure.

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